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Friday, December 6, 2013

Next Big Future - 6 new articles

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Next Big Future"Next Big Future" - 6 new articles

  1. Global Inequality between all people declined from 1988 to 2008 for the first time since 1760
  2. Nobel Prize Winner, Independent UK newspaper, and George Church are pretty much saying that we sit on the cusp of the true Transhuman age with radical life extension and regeneration
  3. CRISPR gene editing process getting hyped as opening path to cures for many diseases and for human gene therapy and age of complete genetic engineering of all life
  4. X-Apple Siri Director is taking artificial intelligence into the cloud for Samsung's AI for the Internet of Things
  5. Hypersonic SR72 and the Trijet engine
  6. Microrobots that can be manufactured in bulk and are light activated and can be steered by a magnetic field will enable microfactories
  7. More Recent Articles
  8. Search Next Big Future
  9. Prior Mailing Archive

Global Inequality between all people declined from 1988 to 2008 for the first time since 1760

The period between 1988 and 2008 witnessed the first decline in global income inequality since the Industrial Revolution, reports Branko Milanovic of the World Bank. This trend, however, was driven by a decline in inequality between countries and can only be sustained if inequality within countries is kept in check.

 
There are three methods for calculating global inequality.

Concept 1. When we calculate this concept of inequality, we take all countries with their mean incomes –we have some 150 countries in the world with such data- and calculate the Gini coefficient. China and Luxembourg have the same importance, because we do not take population sizes into account.

Concept 2. Calculate mean income inequality but take population size into account

Concept 3. Calculate inequality of individuals based on actual income of individuals.


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Nobel Prize Winner, Independent UK newspaper, and George Church are pretty much saying that we sit on the cusp of the true Transhuman age with radical life extension and regeneration

The Independent UK is hailing the CRISPR gene editing process as a breakthrough in genetics – described as "jaw-dropping" by one Nobel scientist – has created intense excitement among DNA experts around the world who believe the discovery will transform their ability to edit the genomes of all living organisms, including humans.

 
* they say it is only a matter of time before we are eliminating genetic disease in human embyros
* human trials to eliminate genetic diseases are starting

The developer of the CRISPR gene editing process has talked about genetically enhancing humans.

* Rare double mutants in the myostatin gene have more lean muscle and less body fat
* those with the LRP5 gene have extra strong bones (like the real version of the Bruce Willis movie Unbreakable character
* Those with the PCSK5 gene have 88 percent lower coronary disease
* Those with double CCR5 genes are HIV resistant
* Those with double FUT2 are resistant to stomach flu

George Church wrote the book
Regenesis.


George Church has indicated that we are years from successful regeneration and anti-aging. He has also talked about radically altering human DNA on a genomic scale to achieve increased intellectual, health and physical capabilities.

With Walter Gilbert, Geroge Church developed the first direct genomic sequencing method in 1984 and helped initiate the Human Genome Project in 1984 while he was a Research Scientist at newly formed Biogen Inc. George invented the broadly applied concepts of molecular multiplexing and tags, homologous recombination methods, and DNA array synthesizers. Technology transfer of automated sequencing & software to Genome Therapeutics Corp. resulted in the first commercial genome sequence, (the human pathogen, Helicobacter pylori) in 1994.

George initiated the Personal Genome Project (PGP) in 2005, and, in 2007, he founded the U.S. personal genomics company Knome (with Jorge Conde and Sundar Subramaniam). He does research on synthetic biology and is director of the U.S. Department of Energy Center on Bioenergy at Harvard & MIT and director of the National Institutes of Health (NHGRI) Center of Excellence in Genomic Science at Harvard.

George Church has been advisor to 22 companies, co-founding (with Joseph Jacobson, Jay Keasling, and Drew Endy) Codon Devices, a biotech startup dedicated to synthetic biology, which produces DNA sequences to order. With Chris Somerville, Jay Keasling, Noubar Afeyan, and David Berry he founded LS9, which is focused on biofuels or renewable petroleum technologies.

In 2009 he founded Pathogenica, with Yemi Adesokan, in order to pioneer commercial applications for pathogen sequencing technology.

He has authored and co-authored more than 270 publications and 50 patent




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CRISPR gene editing process getting hyped as opening path to cures for many diseases and for human gene therapy and age of complete genetic engineering of all life

The Independent UK is hailing the CRISPR gene editing process as a breakthrough in genetics – described as "jaw-dropping" by one Nobel scientist – has created intense excitement among DNA experts around the world who believe the discovery will transform their ability to edit the genomes of all living organisms, including humans.

 
The development has been hailed as a milestone in medical science because it promises to revolutionise the study and treatment of a range of diseases, from cancer and incurable viruses to inherited genetic disorders such as sickle-cell anaemia and Down syndrome.

For the first time, scientists are able to engineer any part of the human genome with extreme precision using a revolutionary new technique called Crispr, which has been likened to editing the individual letters on any chosen page of an encyclopedia without creating spelling mistakes.

The technique is so accurate that scientists believe it will soon be used in gene-therapy trials on humans to treat incurable viruses such as HIV or currently untreatable genetic disorders such as Huntington's disease. It might also be used controversially to correct gene defects in human IVF embryos, scientists said.

Nextbigfuture has been covering the RNA guided gene and genome editing CRISPR process for nearly one year.

George Church was involved with the development of CRISPR and it is part of enabling his vision for using genome editing to radically extend human lifespans and enable immunity and cures to all disease.

Light enabled activation of genes would also enhance the precision and capabilities of CRISPR.


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X-Apple Siri Director is taking artificial intelligence into the cloud for Samsung's AI for the Internet of Things

The former director of Apple's Siri is taking Samsung's version of the artificial intelligence system to the next level. Luc Julia, vice president and innovation fellow at Samsung's Open Innovation Center in Menlo Park, Calif., demonstrated SAMI (Samsung Architecture for Multimodal Interactions), the Siri-like system central to Samsung's Internet of Things (IoT) strategy, at the MEMS Executive Congress 2013 in Napa, Calif., Nov. 7-8.

SAMI is an interactive artificial intelligence (AI) similar to Apple's Siri that Julia helped develop when at Apple. Samsung's SAMI, however, goes far beyond Apple's Siri by aggregating sensor data from all types and brands of IoT devices in the cloud. The open system will then allow Samsung ecosystem partners -- some financed by a $100 million accelerator fund -- to perform deep analytics on that data before sending smart advice back to users.


IoT wearables monitor all a person's vital signs and transmit them to the cloud for analysis.(Source: Samsung)

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Hypersonic SR72 and the Trijet engine

There are some more details about the Lockheed Mach 6 hypersonic plane.

Lockheed as been working with rocket propulsion specialists Aerojet for several years on the project, using company funds. Although the design could lead to a Mach 6 unmanned strike aircraft, Lockheed Martin has dubbed it the SR-72, after the company's SR-71 Blackbird manned strategic reconnaissance aircraft that reached Mach 3 but was retired in 1997.

The engine design modifies a standard military turbine such as an F100 or F110 and couples it to a supersonic combustion ramjet (scramjet), using a common inlet and nozzle. Aerojet has been publicizing its Trijet combined cycle concept for some time already, noting that it would bridge the so-called "thrust gap" between turbines that reach Mach 2.5 and scramjets that work above Mach 3.5. Aerojet was merged with the former Pratt & Whitney Rocketdyne business to form Aerojet Rocketdyne earlier this year.

Lockheed Martin said that the design is "affordable" and could be operational by 2030.



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Microrobots that can be manufactured in bulk and are light activated and can be steered by a magnetic field will enable microfactories

One of the main components of a factory is the robots that transport and assemble objects of varying shapes and sizes. When scaling down to the micro level, the steel and wiring that these robots are made of must be replaced by something else—one new idea is peanut-shaped particles that are propelled with light and steered by magnetic fields.

The light-activated docking system could provide the means to manipulate microscopic particles in a wide range of applications. The motion and cargo-carrying phenomena observed with the hematite dockers is based on osmotic/phoretic transport triggered by the photocatalytic properties of the hematite immersed in a reservoir of hydrogen peroxide. The light activation, photocatalysis, of the hematite triggers the activity and develops a concentration gradient of hydrogen peroxide, surrounding the particle. The hematite dockers themselves are made in bulk and are simple single-component particles, the team says.

The self-propelled colloidal hematite dockers can be steered to a small particle cargo many times its size, dock, transport the cargo to a remote location, and then release it. The self-propulsion and docking are reversible and activated by visible light. The docker can be steered either by a weak uniform magnetic field or by nanoscale tracks in a textured substrate. The light-activated motion and docking originate from osmotic/phoretic particle transport in a concentration gradient of fuel, hydrogen peroxide, induced by the photocatalytic activity of the hematite. The docking mechanism is versatile and can be applied to various materials and shapes. The hematite dockers are simple single-component particles and are synthesized in bulk quantities. This system opens up new possibilities for designing complex micrometer-size factories as well as new biomimetic systems.



Arxiv - Photoactivated Colloidal Dockers for Cargo Transportation



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